Isco reasoned the key against City is to go out onto the field with full concentration, and to try and make as few mistakes as possible.
"In the end, it is the small details that make a difference in a Champions League tie," he stated ahead of the first-leg of their round 16 clash.
"As I've said before, we have to go out focused because we have the quality [to win]. We have the trump card of the Bernabéu, which is also very important.
"I believe that the team is confident about doing things right, and it will be a very attractive tie."