Real go to City next week for the second-leg trailing 2-1.
"We have a lot of experience in these big games, so we can rest easy," Varane told UEFA's official website.
"We're just as decisive as before, winning is always our aim and it's in this club's DNA.
"We always come into this games with a hunger to win and with determination. We'll prepare for it and do everything we can, just like we always do in this competition."
Zinedine Zidane's impact at the Estadio Santiago Bernabeu is not something that can be overlooked, and that's something that is recognised within the dressing room too.
"Zidane transmits confidence and calmness," the defender added.
"It's important because it means he supports me and gives me advice.
"He pushed me to take risks and to play higher to help the team play a more offensive style."