The Mexican striker, 30, had not played since he suffered a fractured skull at Arsenal on 29 November.
Wearing protective headgear, Jimenez struck the bar with a free-kick before being replaced by Patrick Cutrone.
Chris Long scored the winner at Gresty Road as Bruno Lage's reign as Wolves boss began in disappointing fashion.
Jimenez was cleared to return in May, but Wolves decided not to risk him for the final game of the season against Manchester United.It was also decided he would miss the Olympic Games even though Mexico were keen to choose the former Benfica forward as an overage player.
Need a VPN? Or seeking to switch? Then support Tribal Football by clicking here to sign up with our official partners NordVPN. Not only will you receive the best VPN experience, but also great discounts by signing up via Tribal Football. Thanks for your support!