The French outfit are down 2-1 heading into the blockbuster clash at the Etihad on Tuesday.
"With Kylian, we will make a decision on his fitness tomorrow," Pochettino said.
"He is going to start the individual training sessions and see if he can be with the team in the end.
"Yes I am worried for him – we want all the players fit and available. We are going to see in the coming hours if he will be available.
"We have a big squad – all the players can do the job. If Kylian is not available, the team has tools an the the quality to try and win."