Rafael Benitez endured another miserable day as nine-man Liverpool crashed 3-1 against Fulham, but Chelsea defeated Bolton for the second time in a week by 4-0. Liverpool's success over Manchester United last week was but a memory as the Reds have now lost six of their last seven games.
Philipp Degen and Jamie Carragher then both saw red within three minutes late on.
Chelsea moved five points clear at the top of the Premier League courtesy of a second 4-0 win of the week over Bolton.
Deco netted the second and Zat Knight scored an own goal before Drogba completed the scoring in injury time.
Struggling Hull did not enjoy any luck on their visit to Burnley, going down 2-0.
Graham Alexander scored with a debatable penalty and Geovanni then saw a brilliant free-kick controversially disallowed before two yellow cards saw him dismissed.
Alexander then struck from long range to make the points safe and continue the Clarets impressive home form.
The Black Cats were then reduced to ten men after Kenwyne Jones was dismissed.
Both teams finished with 10 men after Bilyaletdinov and Carlos Cuellar saw red late on in separate incidents.
Wolves came from behind at Stoke to earn a 2-2 draw.
But defender Jody Craddock scored twice as Mick McCarthy's side earned a valuable point.