Spurs put in one of their most timid performances when losing 2-0 at Anfield on Saturday and it appears to have affected their overall assuredness, evidenced by tonight's 1-0 loss to Gent in the Europa League Round of 32 first leg.
Prior to the defeat to Liverpool, and subsequently Belgium's eighth-placed team, Spurs had gone 11 matches without defeat which suggests to Pochettino that their confidence has decreased since the visit to Merseyside.
"Until the Liverpool game we were having a good run," he told BT Sport.
"We were 11 (without loss), but sometimes, it happened after Liverpool, it's true our confidence dropped a little bit.
"Today was a different competition, we try to win the game, we try to find a way to score goals.
"It wasn't our best game, we created enough chances, but we cannot score."