Tottenham manager Mauricio Pochettino is likely to give two of his top stars a break.
This marks Spurs' fifth game in the past 13 days. And it is one game too many for Alli and Eriksen.
"It was a tough game against PSV in the Champions League. Then they are going to move to the national team I think. It will be tough to play two games," he is quoted as saying by Football.London.
"That is why we need to take care and send them really fresh. That is why we are thinking if they are going to play or not against Palace.
"It is true if you said to me would you prefer all my international players stay here and rest for two weeks without competition, I would say yes. But that is impossible.
"That is why we were talking before about Dele Alli and Christian Eriksen and international duty. It is play, play, then move them there and play again. If you see our schedule for the next few months it will be so tough."