The North London club opted to leave their five England internationals - Harry Kane, Dele Alli, Eric Dier, Kyle Walker and Danny Rose - out of the pre-season tour down under after they competed at Euro2016 following a tough domestic season.
Spurs skipper Hugo Lloris played in the Euro final with France meaning he has remained on holidays while Belgium trio Toby Alderweireld, Jan Vertonghen and Mousa Dembele, as well as Wales left-back Ben Davies, were also left out of the travelling party.
Regarding the big-name omissions, Pochettino empathised with the Spurs fans in Melbourne but insisted that getting them prepared for the 2016/17 season is more important.
"I feel sorry too for our supporters," he said ahead of Tuesday's clash with Juventus at the MCG.
"It would be great if all our players were involved in the tour of Australia.
"We can see last year in Sydney it was amazing the support we received in Australia.
"We feel sorry but I think they (the fans) understand that it is very difficult.
"It was a very difficult decision for me but it is important that they build their fitness after the whole season, a very stressful season and the Euros. It was difficult
"They are not machines. They are people who need to rest, they need recovery. They have 15-20 days, or more, of holidays and for them it is very important to be fit.
"We have a very important season with the Champions League, the Premier League, the FA Cup and the League Cup. We need to be ready to compete and you can appreciate why we made the decision.
"We have made it for the future of the team."