Sergio Aguero was forced off before half-time, going down appearing to be dizzy and struggling to breath. The Argentine was transferred to hospital via an ambulance for further treatment.
The Argentine was making his fifth appearance after missing the start of the season, though he was quiet in attack with Memphis Depay.
After 68 minutes, Gerard Pique was also forced off as he limped down the tunnel with Clement Lenglet replacing him.
These two injuries add to those of Frenkie de Jong, Ansu Fati, Martin Braithwaite, Sergi Roberto, Pedri, Ronald Araujo and Ousmane Dembele who were unavailable for selection due to their own injuries.
On Tuesday, Barcelona face Dynamo Kiev in the Champions League.
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