The PFA have expressed concern over news that Portsmouth players haven't been paid for the second time this season.
The latest developments will lead to further concern for the stability of the Premier League club.
Players' union chief Gordon Taylor has voiced his concern.
Taylor, chief executive of the Professional Footballers' Association, told Sky Sports News: "You can understand much better problems in the Football League and lower down.
"But if that is happening in the Premier League I'm sure it is not good for the image of the game and if it is the case it is not going to be highly thought of at the headquarters of the Premier League either.
"There can't be any good reason in the Premier League with the money they enjoy from television income alone, never mind sponsorship.
"That is what life is about in football, paying wages of the players.
"I thought this had been solved with the change of ownership at the club a few weeks ago. We had this earlier in the season."