Gasperini was sacked by Inter last season.
"I am not taking tomorrow's game as a chance for revenge. I just want my lads to play well and get a result," assured Gasperini.
"Palermo are coming off a great victory in the Sicilian derby, but our place in the table continues to be complicated. It's a tough fixture list and we need to get points against everyone.
"A victory at San Siro would give us that step up in quality and we've also got to change our form away from home."