The Magpies are coming off an impressive 1-0 win against Manchester United at home before the international break.
And they will be hoping to repeat the feat against another top six hopeful.
Lascelles believes they can target Chelsea's inexperience in the game.
"Chelsea do have a young, energetic team but I'm not sure if they have much experience," he said to Sky Sports.
"I think we'll have a good day, it's obviously going to be tough with their quality and pace.
"They have attacking players who can create and hurt you from nothing.
"Experience is massive in football, the small things like running the game down, winning fouls. I do think we can get after them, they are not the biggest team either so maybe [we can exploit] set pieces. I do fancy ourselves."