Harry Kane, Dele Alli, Jan Vertonghen and Serge Aurier are being rested, while Hugo Lloris (elbow), Michel Vorm (calf), Ben Davies (ankle), Harry Winks (ankle), Tanguy Ndombele (groin) and Erik Lamela (hamstring) are sidelined.
Kyle Walker-Peters, Juan Foyth, Japhet Tanganga, Oliver Skipp, Ryan Sessegnon and Troy Parrott should all feature at the Allianz.
"I am not having the time to know all my players well, and this is a great opportunity for some of them to play, for some of them to show what they are capable of," Mourinho told a press conference.
"A player in competition is different to a player training. Some of my boys didn't have the chance to play many minutes in these five matches since I arrived.
"We are going to have an incredible number of fixtures until the new year and I think it is understandable that we are going to make a few changes and we are going to rest a few players and give opportunities to other players."