The Portuguese faces an uncertain future at the Bernabeu as Real struggle to close a 15-point gap on league leaders Barcelona.
Mourinho told RMC Sport: "The La Liga title is impossible now, there is too big a gap. We have to focus on other goals like the Copa del Rey and the Champions League.
"It does no good to obsess over these things, obsession only makes things more complicated. Nothing will be easy.
"We need to stay calm and make the most of every opportunity."