The Eagles have taken just seven points from seven matches at the South London venue, culminating in Monday night's 1-0 home defeat to struggling Sunderland.
Midfielder McArthur has been buoyed by Palace's quality on the road but has made it clear that improved performances on familiar soil need to lift if they are to forge a top-half finish this campaign.
"The Premier League is hard, it doesn't matter who you play against because you're always going to have tough games," said the Scotland international.
"We've had good results away from home and bad results here at Selhurst and we have to make sure we put that right and bounce back against Newcastle on Saturday.
"It's hard to put your finger on why that is, and if we knew what the problem was we'd be doing a lot better, so we need to make it right and take advantage of the big moments in the game."
Palace dropped to 10th position in the wake of the narrow loss to the Black Cats who picked up just their second win courtesy of Jermain Defoe's 80th-minute winner.