The Manchester Evening News says Darmian is close to a securing a transfer away from Old Trafford ahead of the European window closing on Monday.
The out of favour full-back only made seven appearances in all competitions last season and last played for United in the Manchester derby defeat to City in April.
United were willing to let the defender leave last summer with Italian clubs Juventus, Internazionale and Napoli all believed to have been interested in securing his services but the club did not receive an acceptable offer for the 29-year-old.
He is now close to a transfer to an Italian club before the window closes on Monday, September 2.
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