Dortmund were hoping to have a full strength team for the clash, but Sancho will not be traveling with the team.
Sancho and Roman Burki both have respiratory issues, which means they are staying at home.
Both tested negative for COVID-19, but will not be with the squad as a precaution.
Sancho is being linked with a move to Manchester United, with the transfer deadline fast approaching.
For their part, Dortmund have stated Sancho will stay this summer and will not be sold.