That was his 10th of the season, making him the third Red Devils star over the age of 33 to reach that milestone in one year.
The veteran striker also matched the most goals scored by a Uruguayan for United, which was set by fellow countryman Diego Forlan.
The 41-year-old, now the manager of Atenas de San Carlos, had a less than fruitful spell at Old Trafford - scoring 17 in 98 matches.
Cavani has already reached that total in just 39 games - 59 matches less than his compatriot.
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