Manchester United captain Gary Neville says they can't replace former teammate Cristiano Ronaldo, now of Real Madrid.
Neville said: "We've seen great players leave the club before and coped. I played with Roy Keane for more than 10 years and I never thought we'd replace him.
"We never will, just like we won't replace Ronaldo like for like, but we can adapt. Roy left, Peter Schmeichel left, Eric Cantona left, but the club has remained successful.
"Look at how Michael Carrick and Darren Fletcher have performed in the last two years and you have to say we've survived Keane's exit.
"We'll do the same with Ronaldo. Losing somebody who scores that many goals is always going to be a blow, but there is more than one way to skin a cat.
"Nani and Ji-Sung Park will try to make that position their own, while the goals issue isn't a problem.
"Michael Owen has joined us and you might find Wayne Rooney flourishing. Dimitar Berbatov can bang them in as well."