Neville said: "We've seen great players leave the club before and coped. I played with Roy Keane for more than 10 years and I never thought we'd replace him.
"We never will, just like we won't replace Ronaldo like for like, but we can adapt. Roy left, Peter Schmeichel left, Eric Cantona left, but the club has remained successful.
"We'll do the same with Ronaldo. Losing somebody who scores that many goals is always going to be a blow, but there is more than one way to skin a cat.
"Nani and Ji-Sung Park will try to make that position their own, while the goals issue isn't a problem.