Ole Gunnar Solskjaer hinted Anthony Martial and Jesse Lingard could return to Manchester United's starting line-up on Saturday.
The pair started on the bench on Wednesday night's loss to Barcelona.
But Solskjaer says he will make changes for the visit of West Ham United at Old Trafford.
He said: "I've still got options of course to rest one or two because there are games coming up and they'll all play a part.
"We had players on the bench on Wednesday night like Jesse (Lingard) and Anthony (Martial) who normally start games.
"There will be a couple of changes. Let's see what we'll decide on."