Victor Lindelof missed Manchester United's win over Chelsea due to illness.
The Swede was replaced at centre-back by Eric Bailly, who impressed alongside Harry Maguire.
Speaking to MUTV before the game, manager Ole Gunnar Solskjaer said: "Victor has fallen ill. Eric has been champing at the bit recently.
"He's played a couple of behind-closed-door games with the Reserves. He's ready; hopefully he'll get a good night."