Neville suffered a painful experience in his four months in charge at Valencia – where he won just ten of his 28 matches.
Speaking to Sky Sports, Neville said: “I always say 'never say never' because my love of football is too great, but I genuinely believe it will be very difficult for me to go back into coaching because of my commitment now to so many different things.
“It's my obligation to deliver Salford City to the Football League. It's my obligation to roll out Hotel Football internationally.
“It's my obligation to deliver high-end restaurants with Michael O'Hare. It's my obligation to deliver St Michael's, which I believe is the best development in Manchester.
“I can't go back into coaching now in the short term – the next five years – and the reality of it is I don't want to.
“It could be that I'm no longer ever a coach in football but that's not a loss. Some people might think it is, but the fact of the matter is it's not to me."