The World Cup winner, who has been sidelined from injury recently, is set to return to full training next week.
Before then, on Sunday, Ole Gunnar Solskjaer's men face Everton in the Premier League, with the fixture due to be the 4,000th in a row in which the Red Devils have included at least one academy graduate.
"I've said to a lot of the young players who have been with the first team: 'Guys, you don't know how lucky you are,'" says Pogba, speaking to United's official website.
"Unfortunately for us, we've had a lot of injured players and it's therefore a big chance for the young players to be involved with the first team.
"They have the chance to do well and stay there. So, I said to them: 'Take this luck and take this opportunity because it's important until the other players come back fit.'
"You never know, there could be an injured player and a young player comes in and plays a great game and they stay with the first team until the end of their career.
"So, I've told them: 'Guys, be ready and always take the opportunity.' If they have the quality to be with the first team then why not take the opportunity and play and enjoy yourself?
"Mason [Greenwood], since the first training session that I saw him in, and Brandie [Brandon Williams], Jimmy [James Garner], Angel [Gomes], Chongy [Tahith Chong] and all the players.
"Axel [Tuanzebe] as well, although I don't see him as a young guy, for me, he has been in the first team for a long time, Timo [Tim Fosu-Mensah] as well, but the younger ones, they have the quality, they have everything to be in the first team.
"They've been playing and having some minutes and they should enjoy it when they're on the pitch and work hard.
"Mason is scoring goals, Brandie has been playing games like he's been there for six months already.
"This is what the club is about and what the manager wants."