De Gea broke down early into their training session ahead of tonight's Euro 2020 round of 16 clash with Croatia.
Spain sources say the keeper has collected a hamstring strain and is almost certainly out of the Croatia tie. De Gea is coach Luis Enrique's only injury concern going into the game.
The United keeper hasn't played a single minute of the tournament with Athletic Bilbao keeper Unai Simon favoured by Enrique.
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