Scholes was commenting after United's 2-2 draw at Champions League group opponents Atalanta.
He said, "Tonight was again a little bit messy. As soon as Raphael Varane went off it went all over the place again, really shaky. The quality in the middle of the pitch was not great.
"Harry Maguire - I don't know if he is is injured or has a hangover from the Euros, he just does not look right. He is all over the place.
"Pep [Guardiola] would think he has got a good chance of winning the derby on Saturday. With no Varane it makes it more difficult for United. They have quality to score goals and create chances but United have to defend properly.
"If it was not for that second goal it was a mess. Again, Cristiano Ronaldo has pulled his team out of the mire from a poor second half."
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