The 19-year old, who was born in Amsterdam, spent eight years with de Godenzonen before moving to Old Trafford in 2014.
Fosu-Mensah recently made his return from injury in United's clash with Crystal Palace on Sunday, and he will be hoping to get the opportunity to play against his old club and some former teammates.
"It's my old team (on Wednesday). And it's a nice game, a Europa League final," said Fosu-Mensah.
"It's a big game, and as a football player you want to be involved in big games like this and that's what my focus is on. I played there for eight years so it's definitely extra special.
"I know a couple of players and I speak to them. We have spoken, but not about the game."