The Sun says the 20-year-old Dutchman is struggling to settle in Turin - and that could pave the way for a potential move to Old Trafford.
United chiefs know wantaway France midfielder Paul Pogba, 27, has only a year on his contract this summer as his transfer fee dwindles.
The World Cup winner is now said to be worth only £31m, with transfer fees plummeting amid the coronavirus pandemic. Pogba would jump at the chance of a return to Juve, after leaving in 2016 in a world record £89m deal.
And Red Devils boss Ole Gunnar Solskjaer would welcome the opportunity of landing De Ligt - one of the highest-rated defenders in the world game - to play in his new three-man backline alongside the likes of skipper Harry Maguire, Victor Lindelof and Luke Shaw.