United went onto win at Tottenham Hostspur stadium 3-1 on Sunday.
The hosts had been on top in the very early stages of the match, but Maguire was left unhappy by Reguilon's actions in the awarding of a free-kick.
Paul Pogba was attempting to tackle Tottenham full-back Reguilon, but was penalised for appearing to put his arm across the Spaniard.
It seemed to be a soft foul for referee Chris Kavanagh to award and Red Devils skipper Maguire was left raging by the decision and Reguilon's actions.
“Hey Sergio, f*** off," the centre back was heard saying by journalists covering the game, reports the Mirror.