Having fielded a strong line-up at Aston Villa on Sunday, Solskjaer is expected to make wholesale changes against Leicester before recalling more of his first-choice players at home to Liverpool 48 hours later. Both Leicester and Liverpool are battling for a fourth place finish.
"Talking about integrity in the league and stuff, don't blame me when I have to make changes because I have to," he said. "It's not safe for them to play all four so I have to prioritise.
"I wish I could have said 'let's go full out in all the games' but it's impossible. That's the hard bit for me, knowing if I do play this 11 on Tuesday and then again on Thursday it's impossible. I run too much of a risk in injuring them."
Solskjaer will wait until Tuesday before deciding on his team after he has assessed the players, but expects to include some youngsters in the squad.
"They're in contention, definitely," he added. "They're in the first-team squad they're training with us every day, so I would think that some of the young boys will get an appearance definitely.
"If it's coming on towards the end or it's starting I don't know because I don't know how the players will be on Tuesday when we see them.
"We will sit down with the sports scientists on Monday. We can have a theoretical team now but we'll have to see how they react when they come in and then pick a team Tuesday afternoon."