Solskjaer has noticed a recent trend for teams to try and mark the Portuguese playmaker out of the game, a situation which calls on creativity to come from elsewhere.
Fernandes has been directly involved in 25 of United's 53 Premier League goals this term and Solskjaer has urged his teammates to "step forward" if his influence is diluted against Manchester City.
"I think taking responsibility is important for everyone when they play football. Don't wait for things to happen, you've got to make things happen," he said.
"And we expect everyone to be a leader, everyone to take that responsibility. Of course it might be Bruno, I know that teams are trying to man-mark him at times and that's not a dig at anyone, that's just that sometimes in football they try to stop your best player. And someone else will have to step forward.
"Bruno might find a position, make space for others, create. He has created chances for others even when he has not touched the ball. And you see others have created chances for Bruno when they've not touched the ball.
"It is about the movement and creating space for your team-mate and taking that responsibility. We have had big moments in these big games. Chances that we would normally put away and then everything is rosy, everyone says we are the best thing since sliced bread."