Van de Beek played against Southampton on Sunday and had a swollen ankle after the game.
He did come on in the 3-1 loss to Paris Saint-Germain at home on Wednesday in the Champions League, but did not start.
"We know that we play against a good team, we need some fresh legs out there with Scott, he's just got back from injury," Solskjaer told MUTV.
"Anthony [Martial] was supposed to play against Southampton and is looking sharp again.
"With Edinson [Cavani] and the impact he made [two goals against Southampton] , it was always the case that I'd looked at this game with Edinson up front."