Both came off the bench in Wednesday's 2-0 win over Newcastle, with Lukaku scoring United's first and Sanchez setting up the second.
And manager Ole Gunnar Solskjaer has confirmed the pair are likely to start against the Royals at Old Trafford.
"There will be a few changes [for the game] and they will [all] get a chance," Solskjaer said.
"Some of them are itching now to play, of course. [I want to] get Lukaku a start, get Sanchez a start. That's important for them because they need more game time."