Lindelof performed poorly against Huddersfield Town on Saturday after coming on for the injured Phil Jones. His mistake for the Terriers second goal ultimately cost United the match.
The Swede has struggled to adjust to life in the Premier League since joining from Benfica in the summer.
And the Daily Star claims that Mourinho is ready to start Tuanzebe in place of Lindelof when the Red Devils make the trip to Wales.
Tuanzebe, 19, has yet to feature for the first team this season