Owen faces a rough reception tomorrow when he returns to Liverpool - the club he served for eight years.
United boss Ferguson said: "I don't think it will bother Michael. Everyone wants to be liked but he's got the experience to handle it. It will be interesting to see what kind of reaction he gets.
"There have been very few players who have played for both clubs.
"Paul Ince got a bad reception from our fans when he joined Liverpool.
"Michael may well get that again on Sunday but it is difficult to say."