The Three Lions went into the break 2-0 up thanks to goals through Ben Chilwell, his first for England, and Bukayo Saka, with both brilliantly set up by Phil Foden.
However, England players were frustrated with Andorra's five-at-the-back approach, and tensions boiled over at the end of the half with the Manchester United winger.
Sancho was spotted exchanging heated words with Andorra's right-back Jesús Rubio Gómez as the two left the pitch and into the tunnel.
The Daily Star says tensions boiled over as Sancho conceded a cheap free-kick before kicking the ball away, receiving a yellow card.
And Gomez was less than impressed with the wingers actions as he voiced his displeasure to the referee before leaving a late challenge on the Englishman.
Sancho wasn't happy with the challenge, and he let Gomez know as the pair left the field and down the tunnel.
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