The Citizens midfielder will be hoping that he can perform at his best on Sunday, as they look to close the six point gap between the two teams at Anfield.
De Bruyne knows that getting a positive result is vital, as City do not want to fall any further behind in the title race.
"The big games are the ones you want to play, and if you want to compete for titles you have to be the best," he told reporters.
"The media will make a lot of it, and people have been talking about it for the whole week, even before the Champions League, but we just do our job, keep calm and prepare ourselves.
"I prefer to play in [a big atmosphere] than when there is nobody. Professionals want t play in front of 50, 60, 70, 80 thousand people and it makes it worthwhile.
"You train all your life to get to the big stages. I want to compete for titles and to be the best, and to do that you have to win against the best."