City are preparing for a tough test against a resilient United side, who notched an impressive win at Juventus on Wednesday night.
But Bernardo has played down the impact of the clash, insisting it is just one of many league games the Citizens must win.
He is quoted by the Daily Star as saying: "We don't know that [importance of the game]. It is still early. For sure it is an important game, like any other one, because we are playing for three points and we want to win every time we play in the Premier League or any other competition.
"It is just one more game. Of course for the fans it means a little bit more because it is a derby and because we are playing against a contender.
"So if we win we are not only winning three points but taking three points from them as well. It is a very important game - but it is just one more."