Reports in the Spanish press have suggested that De Bruyne could want to play for Real in the prime of his career.
But Guardiola believes that it would take a lot for the Citizens to part with one of the best midfielders in the world.
De Bruyne has a goals plus assists contribution of nearly one a game this season.
"Could De Bruyne play in Madrid? Florentino will have to call me," Guardiola joked on Post United in an interview with YouTuber 'DjMaRiiO'.