Laporte is ready to play 90 minutes against Real Madrid on Wednesday night despite the defender asking to be substituted during Saturday's 1-0 win at Leicester.
"He asked me to be subbed," Guardiola said. "He's not injured. We cannot forget he has been out for four or five months injured. They run a lot, (Jamie) Vardy, Kelechi (Iheanacho), (Harvey) Barnes, they are all so fast.
"It was quite different against West Ham (on Wednesday) where they was only one striker so it was easier to control, but he's OK."
Asked if Laporte was ready to play the full match at the Bernabeu on Wednesday, Guardiola simply said: "Yes."