De Bruyne missed the 2-0 win over Dinamo Zagreb on Tuesday due to a groin injury.
"It's not serious, but today he could not play," Guardiola told a news conference of De Bruyne's injury. "We'll see next Sunday.
"For the weekend, right now I don't know. Maybe he can get fit. We are going to see if we can take a risk.
"I think after the international break he will be fit."