City will bid to overturn their Champions League quarter-final first leg 1-0 deficit at the Etihad on Wednesday night.
And De Bruyne fears Spurs will be just as tough to crack without the England captain, who is out for the season with ankle ligament damage suffered during that meeting in London.
He said: “Harry Kane is a wonderful striker, but it would be disrespectful to the other guys. They won against us without him when he went off last week and they have brilliant players [Kane-less Tottenham hammered Huddersfield 4-0 at the weekend, with Lucas Moura scoring a hat-trick].
“Earlier they won so many games without him before and they are still a very good team without him. Obviously he's a really good player, but it's not going to change anything.
“It will be a great game — a good atmosphere and, hopefully, a good game.
“For us, it's all or nothing."