United couldn't find the finishing touch and a breakaway Besiktas goal proved to be the only difference between the two sides.
"We're disappointed to lose because I think we could have won the game," Macheda told MUTV. "We were unlucky because we had quite a few chances but couldn't take them.
"I was quite happy with my performance. If I had scored it would have better, but maybe next time I will score."
Having had his second taste of Champions League action, the 18-year-old striker is aiming to take even more first-team opportunities.
"I hope to play as many games as possible, but it's not easy because there are many good players in front of me. But when I get my chance I hope to take it.
"Now we need to go to Germany and get a result to win the group. But we are confident that we can win the game and win the group, definitely."