Kane joined the League One club last month after spending the first-half of the season on loan at Dutch club, Groningen.
Kane powerfully struck home with his right foot in the 89th minute from a Ricardinho cross, to equalise the scores at 2-2.
Ryan Ledson ended up scoring the winning goal for Oxford in the 94th minute.
Kane took to Twitter to celebrate his goal and thank the fans at his new club:
Buzzing to score on my debut for @OUFCOfficial and get 3 Big points. Oxford fans were unreal by the way. bring on the next one. Great to be home. pic.twitter.com/9vIuNfzQg5
— Todd Kane (@Toddy_Kane) February 3, 2018
Kane now has one goal from one appearance at Oxford United.