After Sunday's 2-2 draw, Klopp vowed to field Liverpool's "kids" in the clash at Anfield, which falls in the club's winter break.
And Wijnaldum says it is important for his teammates to take advantage of the break.
"Since I've been in the Premier League I've played the season without a winter break but I also know, before I came to the Premier League, how good it is for a player to have some rest," Wijnaldum told Sky Sports News.
"After the rest you can go again. Your body is more rested than if you keep on going, so that's a good thing.
"As a player you want to be involved in every game there is but you also have to deal with your body and sometimes your body just says that it is not the right choice to do.
"You just have to see how the situation is but if the manager decides that the younger players are going to play the game then we should accept it."