The Reds are ahead 3-1 after the first leg last week, and Klopp hopes home-field advantage can see his team reach the semi-finals.
Asked what approach he thinks Benfica will take, Klopp told reporters: "I don't know, but what I know is what I would do: I would go for it, full throttle.
"I would go for it, put us under pressure, try to score early, if not, try to score a bit later. That's what you do and that's what we expect.
"Benfica respected us before, how we respected them before the game. But during the game I'm pretty sure Benfica felt, 'OK, here and there, it was quite good, we were close.' But now, bad news for Benfica – it's Anfield.
"It's Anfield and they don't only play against us, they play against the whole crowd. It's cool in a specific way but we hope we can use that. I said it a couple of times, we want to be the one team nobody wants to play against, that's what we want to be. And hopefully we can be that tomorrow night."
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