The Senegalese missed the 3-1 win over West Ham United on Sunday.
Asked about Mane's injury, Klopp answered: "It happened in the game against Tottenham, so it is nothing too serious, but serious enough to not be involved today.
"[We hope] that this is something like this doesn't happen again. We had less than 72 hours between games and no-one wants to hear that, but it's like this.
"We have to try to make sure the boys' recovery is as good as possible, but Bobby (Firmino) is fine."
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