The Germans found themselves behind at the Volkswagen Arena with just over 10 minutes when Belgium international Divock Origi converted from the penalty spot.
The 19-year old, who signed with Liverpool in the summer before being loaned back to Lille, stepped up to give the French club the lead after Wolfsburg left-back Ricardo Rodriguez had handled the ball in the area.
But five minutes later, former Chelsea midfielder Kevin de Bruyne got the home side back on level terms when he superbly volleyed home from the edge of the area to finally break down the Liguen 1 side's resistance.
Dieter Hecking's Wolves managed 24 shots on goal during the 90 minutes but Lille's Nigerian goalkeeper Vincent Enyeama was at his commanding best to continually deny the Bundesliga side until de Bruyne's stunner.
In Group H's other clash, Everton held Kuban Krasnodar 1-1 in Russia to remain top of the table with four points, two ahead of tonight's opponents as well as Lille, while Wolfsburg remain bottom with just one draw from their two outings.
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