Klopp's men thumped the Red Devils 3-1 in the return fixture earlier in the season, which turned out to by Jose Mourinho's final game in charge.
"The way they are setting up now, they're really attacking, on the front foot, exciting to watch," said Carragher on Viasport.
"Maybe that will give Liverpool more chance in terms of space at Old Trafford.
"Whenever Mourinho's teams played against Liverpool at Old Trafford there was very little space for Mane and Salah, they always found it really difficult in the last couple of years. So maybe that might change, maybe a more open game.
"Liverpool's record is really poor at Old Trafford since Sir Alex Ferguson left so that is something that has to change. If Liverpool could get a result there they have a big week, Watford then Everton.