The winger was taken off before half-time in the World Cup qualifier after hurting his ribs while challenging for a header.
The Reds are now waiting on the results of an X-ray to determine the extent of the injury.
Mane was crocked in Senegal's 1-1 draw in the Togolese capital Lome.
Coach Aliou Cisse put out a strong side despite the visitors having already qualified for March's play-offs, when Africa's five World Cup teams will be decided.
Skipper Jordan Henderson will miss England's upcoming clash with San Marino after undergoing a scan.
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