The Dutch centre-back will walk out at St Mary's just six weeks after completing a record-breaking £75million switch to Anfield.
“What can you do? Maybe they can boo the whole game," Van Dijk said.
“What can you do about it? You can't do anything about it.
“I made the decision, I have enjoyed every bit of it and I am very grateful for everything that they (Southampton) did for me. I have moved on, they have moved on.
“I know they are struggling and we need to win. I am going there with only one mindset and that is to win.
“Obviously it will be nice to see the players I have played with and the friends I have there but, for me, it is going to be about one thing only and that is to win the game."